miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2

doi:10.1016/j.febslet.2012.08.023

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	miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2
	Wu, Ning 1; Xiao, Lin 1; Zhao, Xiangzhong 2; Zhao, Jin 1; Wang, Jianpeng 3; Wang, Fengxia 1; Cao, Shousong 4; Lin, XiuKun 1,5; Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
	2012-11-02
发表期刊	FEBS LETTERS
ISSN	0014-5793
卷号	586 期号:21 页码:3831-3839
文章类型	Article
摘要	microRNAs (miRNAs) play important role in regulating cancer stem cell self-renewal and differentiation, but the expression prolife of miRNAs in glioma stem cells (GSCs) has not been addressed. Here, we found that CD133 positive GSCs possess a unique miRNAs profile compared to CD133 negative glioblastoma cells. miR-125b, as one of neuronal miRNAs, is the most significantly down-regulated miRNAs and overexpression of miR-125b inhibits the proliferation of CD133 positive GSCs and reduces the expression of "stem" marker. Furthermore, two binding sites for miR-125b are identified in the 3'UTR of E2F2 and overexpression of miR-125b in CD133 positive GSCs represses the endogenous level of E2F2 protein. This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
关键词	Microrna Glioblastoma Stem Cell Brain Tumor Microrna-125b E2f2
学科领域	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
DOI	10.1016/j.febslet.2012.08.023
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000310529000011
引用统计	被引频次：70[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/12361
专题	实验海洋生物学重点实验室
通讯作者	Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Shandong Acad Med Sci, Key Lab Modern Med & Technol Shandong Prov, Inst Basic Med, Jinan 250062, Peoples R China 3.Qingdao Med Univ, Affiliated Hosp, Inst Brain, Qingdao 266003, Peoples R China 4.Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA 5.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wu, Ning,Xiao, Lin,Zhao, Xiangzhong,et al. miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2[J]. FEBS LETTERS,2012,586(21):3831-3839.
APA	Wu, Ning.,Xiao, Lin.,Zhao, Xiangzhong.,Zhao, Jin.,Wang, Jianpeng.,...&Lin, XK .(2012).miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2.FEBS LETTERS,586(21),3831-3839.
MLA	Wu, Ning,et al."miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2".FEBS LETTERS 586.21(2012):3831-3839.

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