| Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells | |
| Wei, Jianteng1,3; Liu, Haizhou1; Liu, Ming1; Wu, Ning1; Zhao, Jin1,3; Xiao, Lin1,3; Han, Lijun1; Chu, Edward4; Lin, Xiukun1,2; Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China. | |
| 2012-10-01 | |
| 发表期刊 | ONCOLOGY REPORTS
 |
| ISSN | 1021-335X |
| 卷号 | 28期号:4页码:1339-1345 |
| 文章类型 | Article |
| 摘要 | The antitumor activity of oleanolic (OA) has attracted attention due to its marked antitumor effects and pharmacological safety. In the present study, the effects of the combination of OA and 5-fluorouracil (5-FU) on Panc-28 human pancreatic cells were studied. The results showed that combined use of OA and 5-FU synergistically potentiated cell death effects on Panc-28 cells, and the pro-apoptotic effects were also increased. Further study revealed that the combined treatment could enhance mitochondrial depolarization, lysosomal membrane permeabilization (LMP) and leakage of cathepin D, while the release of cytochrome C did not display significant changes. The expression of apoptosis related proteins was also affected in cells treated with the combination of OA and 5-FU, including activation of caspases-3 and the expression of Bcl-2/Bax, survivin and NF-kappa B. Our results provide evidence that combination of OA and 5-FU may serve as a novel strategy for the treatment of pancreatic cancer. |
| 关键词 | Apoptosis Oleanolic Acid 5-fluorouracil Pancreatic Cancer Cells Synergism |
| 学科领域 | Oncology |
| DOI | 10.3892/or.2012.1921 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309315400031 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/12239 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15232 USA |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Wei, Jianteng,Liu, Haizhou,Liu, Ming,et al. Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells[J]. ONCOLOGY REPORTS,2012,28(4):1339-1345. |
| APA | Wei, Jianteng.,Liu, Haizhou.,Liu, Ming.,Wu, Ning.,Zhao, Jin.,...&Lin, XK .(2012).Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells.ONCOLOGY REPORTS,28(4),1339-1345. |
| MLA | Wei, Jianteng,et al."Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells".ONCOLOGY REPORTS 28.4(2012):1339-1345. |
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