| Fucoidan Protects against Lipopolysaccharide-Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia | |
| Cui, Yan-Qiu1,2; Jia, Yan-Jun1; Zhang, Ting3; Zhang, Quan-Bin4; Wang, Xiao-Min1; Wang, XM (reprint author), Capital Med Univ, Key Lab Neurodegenerat Dis, Minist Educ, 10 Xitoutiao, Beijing 100069, Peoples R China. | |
| 2012-10-01 | |
| 发表期刊 | CNS NEUROSCIENCE & THERAPEUTICS
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| ISSN | 1755-5930 |
| 卷号 | 18期号:10页码:827-833 |
| 文章类型 | Article |
| 摘要 | Background Fucoidan, a sulfated polysaccharide extracted from brown algae, possesses potent antiinflammatory effects. Aims To examine the effect of fucoidan treatment on inflammation-mediated dopaminergic neuronal damage and its potential mechanisms. Methods Microglial activation and injury of dopaminergic neurons were induced by intranigral injection of lipopolysaccharide (LPS), and the effects of fucoidan treatment on animal behavior, microglial activation and survival ratio of dopaminergic neurons were investigated. We further observed the efficacy of fucoidan on tumor necrosis factor-alpha (TNF-a) and the production of reactive oxygen species (ROS) in LPS-activated primary microglia. Results Fucoidan significantly improved the behavioral manifestation, prevented the loss of dopaminergic neurons and inhibited the deleterious activation of microglia in the substantia nigra pars compacta of LPS-treated rats. Further in vitro experiments indicated that the excessive production of TNF-a and ROS in LPS-induced primary microglia were significantly inhibited by fucoidan administration. Conclusion This is the first study to demonstrate that fucoidan possesses neuroprotective effects on injured dopaminergic neurons in a LPS-induced animal model of Parkinson's disease. The mechanisms underlying these effects may include its potent down-regulation of intracellular ROS and subsequent proinflammatory cytokine release in LPS-activated microglia. |
| 关键词 | Fucoidan Microglia Parkinson's Disease Reactive Oxygen Species Tumor Necrosis Factor-alpha |
| 学科领域 | Neurosciences ; Pharmacology & Pharmacy |
| DOI | 10.1111/j.1755-5949.2012.00372.x |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000309186000004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/12225 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Wang, XM (reprint author), Capital Med Univ, Key Lab Neurodegenerat Dis, Minist Educ, 10 Xitoutiao, Beijing 100069, Peoples R China. |
| 作者单位 | 1.Capital Med Univ, Key Lab Neurodegenerat Dis, Minist Educ, Beijing 100069, Peoples R China 2.Capital Med Univ, Yanjing Med Coll, Beijing 100069, Peoples R China 3.Capital Med Univ, Dept Neurobiol, Beijing 100069, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Yan-Qiu,Jia, Yan-Jun,Zhang, Ting,et al. Fucoidan Protects against Lipopolysaccharide-Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia[J]. CNS NEUROSCIENCE & THERAPEUTICS,2012,18(10):827-833. |
| APA | Cui, Yan-Qiu,Jia, Yan-Jun,Zhang, Ting,Zhang, Quan-Bin,Wang, Xiao-Min,&Wang, XM .(2012).Fucoidan Protects against Lipopolysaccharide-Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia.CNS NEUROSCIENCE & THERAPEUTICS,18(10),827-833. |
| MLA | Cui, Yan-Qiu,et al."Fucoidan Protects against Lipopolysaccharide-Induced Rat Neuronal Damage and Inhibits the Production of Proinflammatory Mediators in Primary Microglia".CNS NEUROSCIENCE & THERAPEUTICS 18.10(2012):827-833. |
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