| Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration | |
| Li Ting1,2; Guo Shuju1; Ma Lin3; Yuan Yi1; Han Lijun1; Han, LJ (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China. | |
| 2012 | |
| 发表期刊 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| ISSN | 0254-4059 |
| 卷号 | 30期号:1页码:22-28 |
| 文章类型 | Article |
| 摘要 | Gelatin has been used in hard capsule shells for more than a century, and some shortcomings have appeared, such as high moisture content and risk of transmitting diseases of animal origin to people. Based on available studies regarding gelatin and vegetable shells, we developed a new type of algal polysaccharide capsule (APPC) shells. To test whether our products can replace commercial gelatin shells, we measured in-vivo plasma concentration of 12 selected volunteers with a model drug, ibuprofen, using high performance liquid chromatography (HPLC), by calculating the relative bioavailability of APPC and Qualicaps (R) referenced to gelatin capsules and assessing bioequivalence of the three types of shells, and calculated pharmacokinetic parameters with the software DAS 2.0 (China). The results show that APPC shells possess bioequivalence with Qualicaps (R) and gelatin shells. Moreover, the disintegration behavior of four types of shells (APPC, Vegcaps (R), Qualicaps (R) and gelatin shells) with the content of lactose and radioactive element ((99m)Tc) was observed via gamma-scintigraphic images. The bioavailability and gamma-scintigraphic studies showed that APPC was not statistically different from other vegetable and gelatin capsule shells with respect to in-vivo behavior. Hence, it can be concluded that APPCs are exchangeable with other vegetable and gelatin shells. |
| 关键词 | Bioavailability Bioequivalence Gamma-scintigraphy Vegetable Capsules Gelatin Capsules |
| 学科领域 | Limnology ; Oceanography |
| DOI | 10.1007/s00343-012-1011-4 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000299040100002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/12224 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Han, LJ (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Qingdao Univ, Pharmacol Lab, Affiliated Hosp, Coll Med, Qingdao 266003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Ting,Guo Shuju,Ma Lin,et al. Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2012,30(1):22-28. |
| APA | Li Ting,Guo Shuju,Ma Lin,Yuan Yi,Han Lijun,&Han, LJ .(2012).Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,30(1),22-28. |
| MLA | Li Ting,et al."Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 30.1(2012):22-28. |
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