| A new ketosteroid from red alga Acanthophora spicifera | |
| Shi Dayong; Guo Shuju; Fan Xiao | |
| 2011-05-01 | |
| 发表期刊 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| ISSN | 0254-4059 |
| 卷号 | 29期号:3页码:674-678 |
| 文章类型 | Article |
| 摘要 | A new ketosteroid, along with six known steroids, was isolated from the ethanolic extracts of red alga Acanthophora spicifera (Vahl.) Boergesen. The structures, identified using chemical and spectroscopic methods including 2D NMR, were: (1) 22-hydroxy-5 alpha-cholest-3,6-dione, (2) 6-hydroxycholest-4-ene-3-one, (3) cholest-4-ene-3,6-dione, (4) cholest-5-ene-3 beta-ol, (5) 5 alpha-cholestane-3,6-dione, (6) beta-Sitosterol and (7) Saringosterol. The MTT method was used to test the cytotoxicity of the compounds against the human cancer cell lines, HCT-8, Bel-7402, BGC-823, A549 and HELA. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity against human cancer cell lines.; A new ketosteroid, along with six known steroids, was isolated from the ethanolic extracts of red alga Acanthophora spicifera (Vahl.) Boergesen. The structures, identified using chemical and spectroscopic methods including 2D NMR, were: (1) 22-hydroxy-5 alpha-cholest-3,6-dione, (2) 6-hydroxycholest-4-ene-3-one, (3) cholest-4-ene-3,6-dione, (4) cholest-5-ene-3 beta-ol, (5) 5 alpha-cholestane-3,6-dione, (6) beta-Sitosterol and (7) Saringosterol. The MTT method was used to test the cytotoxicity of the compounds against the human cancer cell lines, HCT-8, Bel-7402, BGC-823, A549 and HELA. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity against human cancer cell lines. |
| 关键词 | Red Alga Acanthophora Spicifera (Vahl.) Boergesen Steroids Cytotoxic Activity |
| 学科领域 | Marine & Freshwater Biology ; Oceanography |
| DOI | 10.1007/s00343-011-0183-7 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000292558100022 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/11993 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi Dayong,Guo Shuju,Fan Xiao. A new ketosteroid from red alga Acanthophora spicifera[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2011,29(3):674-678. |
| APA | Shi Dayong,Guo Shuju,&Fan Xiao.(2011).A new ketosteroid from red alga Acanthophora spicifera.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,29(3),674-678. |
| MLA | Shi Dayong,et al."A new ketosteroid from red alga Acanthophora spicifera".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 29.3(2011):674-678. |
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