Domestication Relaxed Selective Constraints on the Yak Mitochondrial Genome

doi:10.1093/molbev/msq336

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	Domestication Relaxed Selective Constraints on the Yak Mitochondrial Genome
	Wang, Zhaofeng 1; Yonezawa, Takahiro 2; Liu, Bin 3,4; Ma, Tao 1; Shen, Xin 5; Su, Jianping 6; Guo, Songchang 6; Hasegawa, Masami 2; Liu, Jianquan 1
	2011-05-01
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	28 期号:5 页码:1553-1556
文章类型	Article
摘要	Wild yaks roaming in the high-altitude Qinghai-Tibetan plateau have to maintain high metabolic efficiency. However, domestic yaks do not require such high efficiency because of their limited activity. Hence, domestication may have caused the relaxation of selective constraints on the yak mitochondrial genome because mitochondrial mutations are extremely sensitive to energy-related selective pressures. We have tested this hypothesis by analyzing the mitochondrial genomes of 51 domestic yaks and 21 wild yaks. The results show that the ratio of nonsynonymous/synonymous substitutions in mitochondrial protein-coding genes is significantly higher in domestic yak lineages than those of wild yaks. This genetic difference suggests that the relaxation of selective constraints following the domestication in addition to bottlenecks has allowed faster accumulation of nonsilent substitutions in the yak mitochondrial genome, despite its short domestication history.; Wild yaks roaming in the high-altitude Qinghai-Tibetan plateau have to maintain high metabolic efficiency. However, domestic yaks do not require such high efficiency because of their limited activity. Hence, domestication may have caused the relaxation of selective constraints on the yak mitochondrial genome because mitochondrial mutations are extremely sensitive to energy-related selective pressures. We have tested this hypothesis by analyzing the mitochondrial genomes of 51 domestic yaks and 21 wild yaks. The results show that the ratio of nonsynonymous/synonymous substitutions in mitochondrial protein-coding genes is significantly higher in domestic yak lineages than those of wild yaks. This genetic difference suggests that the relaxation of selective constraints following the domestication in addition to bottlenecks has allowed faster accumulation of nonsilent substitutions in the yak mitochondrial genome, despite its short domestication history.
关键词	Bos Grunniens Domestication Mitochondrial Genome Evolution
学科领域	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
DOI	10.1093/molbev/msq336
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000289841500002
引用统计	被引频次：77[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/11843
专题	实验海洋生物学重点实验室
作者单位	1.Lanzhou Univ, Mol Ecol Grp, Key Lab Arid & Grassland Ecol, Lanzhou, Gansu, Peoples R China 2.Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China 3.Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Urumqi, Xinjiang, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao, Shandong, Peoples R China 5.Chinese Acad Sci, Beijing Genom Inst, Beijing, Peoples R China 6.Chinese Acad Sci, Key Lab Adaptat & Evolut Plateau Biota, NW Inst Plateau Biol, Xining, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhaofeng,Yonezawa, Takahiro,Liu, Bin,et al. Domestication Relaxed Selective Constraints on the Yak Mitochondrial Genome[J]. MOLECULAR BIOLOGY AND EVOLUTION,2011,28(5):1553-1556.
APA	Wang, Zhaofeng.,Yonezawa, Takahiro.,Liu, Bin.,Ma, Tao.,Shen, Xin.,...&Liu, Jianquan.(2011).Domestication Relaxed Selective Constraints on the Yak Mitochondrial Genome.MOLECULAR BIOLOGY AND EVOLUTION,28(5),1553-1556.
MLA	Wang, Zhaofeng,et al."Domestication Relaxed Selective Constraints on the Yak Mitochondrial Genome".MOLECULAR BIOLOGY AND EVOLUTION 28.5(2011):1553-1556.

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